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That means you can use it to avoid any targeted spell, any board wipes that destroy things instead of exiling them or just use it to avoid losing creatures in a big attack

This is, in essence, a sort of reflavour of Morph and Megamorph, and has cards coming in facedown as 2/2 with Ward 2

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Blasphemous ActBlasphemous Act, Chain ReactionChain Reaction, and EarthquakeEarthquake are the kind of spells I'm thinking about here

Combo potential with Ruthless Ripper aside, Missys impressive as a card that makes a 2/2 whenever a creature dies